Study Looks At Genetic Basis of Neutropenia

A new paper by S Gautam, S Kirschnek, I E Gentle, C Kopiniok, P Henneke, H Häcker, L Malleret, A Belaaouaj and G Häcker:

Differentiation of neutrophil granulocytes (neutrophils) occurs through several steps in the bone marrow and requires a coordinate regulation of factors determining survival and lineage-specific development. A number of genes are known whose deficiency disrupts neutrophil generation in humans and in mice. One of the proteins encoded by these genes, glucose-6-phosphatase-β (G6PC3), is involved in glucose metabolism. G6PC3 deficiency causes neutropenia in humans and in mice, linked to enhanced apoptosis and ER stress. We used a model of conditional Hoxb8 expression to test molecular and functional differentiation as well as survival defects in neutrophils from G6PC3−/− mice. 

Read More: Cell Death and Differentiation

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