Tag Archive | Cancer

Reducing GCSF Increases Incidence of Neutropenia

Hematopoietic growth factors

Hematopoietic growth factors (Photo credit: Wikipedia)

A study involving 167 patients was published in the December 1 issue of the Journal of Clinical Oncology and reported that when the use of prophylactic granulocyte-colony stimulating factor (G-CSF) to reduce febrile neutropenia (FN) was decreased in patients receiving chemotherapy for breast cancer, it led to a more than 5-fold increase in FN episodes and an early end to the clinical trial.

In an accompanying study, Dr. Aarts’s research team evaluated the cost effectiveness of pegfilgrastim prophylaxis for FN. They conclude that skipping G-CSF after the first 2 chemo cycles saved an average of €3491 per patient. They estimate that nationwide, this would translate into a saving of €14.3 million each year.

However, this resulted in an unexpected and substantial increase in FN incidence. The researchers calculate that the incremental cost-effectiveness ratio for preventing an FN episode by giving G-CSF with every chemotherapy cycle, compared with only for the first 2 cycles, worked out to €13,112 per patient.

“When one is willing to pay at least €13,122 per patient with FN episodes prevented, 6 cycles of G-CSF prophylaxis is considered a cost-effective strategy,” they conclude.

Read More: Medscape

G-CSF Prophylaxis Recommended

English: pink ribbon


Dutch team is recommending the continued use of primary granulocyte colony-stimulating factor (G-CSF) prophylaxis throughout all chemotherapy cycles in women with early breast cancer who are at high risk of febrile neutropenia (FN). At present, the approach is standard practice in this population.


Read More: G-CSF Prophylaxis Recommended Throughout Chemotherapy in Breast Cancer Patients at Risk for Febrile Neutropenia


Treating Kids’ Cancer With Science And A Pocket Full Of Hope

Dr. Olson draws inspiration and strength from his patients and their families. His decision to work with kids, he says, goes back to something that happened 25 years ago when he was still in training. A 7-year-old girl he was caring for died, and the loss tore at his heart. But his reaction was complicated.

“The night that she died I was walking home, and I was almost skipping or dancing,” Olson says. “I was really light, and I was singing and humming out loud. Neither of these things is typical for me. And it was so absurd to me that this really profound event had happened that day, and I was feeling so opposite.”

So he sat down on a bench and tried to figure out what was going on. It didn’t take him long to realize his mood had to be related to a conversation with the girl’s parents. He’d assumed that after their daughter’s death, they’d want to get as far away from the hospital as possible. But, no.

“They actually tracked me down, and came up and gave me a beautiful warm hug,” Olson remembers. “And they said, ‘Her death to us was as beautiful as her birth, and the reason for that was because of the words you shared with us as we went through this. And we just want you to know that you have a gift, that when medicine doesn’t go the way you want it to, that you can still help families recognize a life doesn’t have to be 90 years [long] to be beautiful.’

“And so I sat there and thought about that for a long time, and I realized that this was a gift that I had,” he says. “And not many people would recognize the gift, or have it or want to share it. But for me it felt like a calling of sorts.”

Olson tore up the applications he’d written for other medical specialties and committed himself to pediatrics. Yet, he also wanted to do research. So he wound up going to the Fred Hutchinson Cancer Research Center in Seattle, where he could practice medicine and be a scientist, too.

In the past 20 years, or so, Olson has cared for hundreds of children with brain cancer. Though many have survived, many haven’t.

Read More: NPR Story

Sign the petition to help save Ariana-Leilani.

GoPetition for ariana-leilani


Talia Joy Castellano Dead: Inspirational YouTube Child Star Dies After 6-Year Battle With Cancer

We regret to announce that Talia Joy Castellano lost her battle to cancer yesterday.  “The bubbly girl who wanted to do something about childhood cancer.”   #‎prayfortalia Talia is 13, a little older than Ariana-Leilani.   They both became sick at about the same age.  In September, Ellen DeGeneres invited the Florida native to appear on her show and revealed that Talia had been chosen to be an honorary CoverGirl.

As Talia says, there should be so many other people helping people.   There is still time to help Ariana-Leilani who suffers from untreated Severe Chronic Neutropenia in Washington DC.   Please sign her petition today:


Dr. Ariel King, On Media Tour Interviews to Save Ariana-Leilani

Ariana-Leilani and her mother Dr. Ariel King

Ariana-Leilani and her mother Dr. Ariel King

Dr. Ariel King, Mother of Ariana-Leilani, has taken to the airwaves to inform the world about Ariana-Leilani’s condition, and what needs to be done to get her relief.  Visit the media page for the latest listings of her appearances.

Ariana-Leilani In the News

Sign the petition to Save Ariana-Leilani: 



Inspirational 10 Year Old, “Live Like Bella,” Loses 6 year Fight to Cancer

Live Like Bella 10 Year Old Loses Fight to Cancer

Live Like Bella 10 Year Old Loses Fight to Cancer

Bella Rodriguez-Torres died after a 6-year battle with rhabdomyosarcoma, a cancerous tumor of the muscles that are attached to bones.   When she was first diagnosed stage IV cancer at 4 years old, doctors only gave Bella four months to live. She surprisingly recovered, and started to walk on her own two feet and the tumors soon disappeared. However, the cancer returned throughout her life, necessitating numerous rounds of chemotherapy, radiation and surgery. She still didn’t give up.

Supporters of Bella began to “Live Llke Bella,” a motto for pursuing everything that life has to offer.
“Live Like Bella means to eat something and enjoy it, savor it, go play with gusto, even the simple things. Do them and enjoy them. Learn something new, get out of your comfort zone and enjoy life,” Ralph explained.

LeBron James adopted the motto. He and his teammate Dwyane Wade wrote the slogan on their shoes before the Miami Heat’s game against the Indiana Pacers on Tuesday.

Live like Bella, please sign 10 year old Ariana-Leilani’s Petition to get needed medicine and medical care for her life-threatening Severe Chronic Neutropenia:


On the Air: The Word of Ariana-Leilani’s Call for Help Is Being Heard

The story of Ariana-Leilani’s plight continues to spread.    Two recent radio programs that featured her story and call for help:

Listen how Ariana-Leilani is not getting needed medicine for her neutropenia, then please sign her petition:



Tips On Care For a Patient with Neutropenia

Ariana-Leilani is not getting needed medicine for her neutropenia, please sign her petition:



Study Looks At Genetic Basis of Neutropenia

A new paper by S Gautam, S Kirschnek, I E Gentle, C Kopiniok, P Henneke, H Häcker, L Malleret, A Belaaouaj and G Häcker:

Differentiation of neutrophil granulocytes (neutrophils) occurs through several steps in the bone marrow and requires a coordinate regulation of factors determining survival and lineage-specific development. A number of genes are known whose deficiency disrupts neutrophil generation in humans and in mice. One of the proteins encoded by these genes, glucose-6-phosphatase-β (G6PC3), is involved in glucose metabolism. G6PC3 deficiency causes neutropenia in humans and in mice, linked to enhanced apoptosis and ER stress. We used a model of conditional Hoxb8 expression to test molecular and functional differentiation as well as survival defects in neutrophils from G6PC3−/− mice. 

Read More: Cell Death and Differentiation

Clouds by Zach Sobiech

Inspirational cancer victim Zach Sobiech, sings his original infectious song about his unfortunate circumstances with over 4 million youtube views.  He recently lost his battle to cancer.  Let’s keep fighting so no children will lose their lives to cancer and other childhood illnesses.  He is an inspiration to all children.  Worth a listen:

Read more: Teen who penned moving farewell song ‘Clouds’ loses battle with cancer