Neutropenia Risk Prompts REMS for Antipsychotic Clozapine

clozapinelabelThe Food and Drug Administration (FDA) has announced changes to prescribing information for the atypical antipsychotic clozapine and a new shared risk evaluation and mitigation strategy (REMS) due to continuing safety concerns and current knowledge regarding the risk of severe neutropenia. Clozapine is indicated for the treatment of resistant schizophrenia and to reduce the risk of recurrent suicidal behavior in schizophrenia and schizoaffective disorders.

The requirements to monitor, prescribe, dispense, and receive clozapine are now incorporated into the new shared Clozapine REMS Program, which replaces the six individual clozapine registries. The REMS program includes all clozapine medicines in order to provide a centralized point of access for prescribers and pharmacists in managing the risk of neutropenia. Starting October 12, 2015, clozapine will be available only through the Clozapine REMS Program.

Important changes to the neutropenia monitoring recommendations and treatment algorithm for clozapine include:

  • Absolute neutrophil count (ANC) is the only test result accepted in the Clozapine REMS Program to monitor for neutropenia.
  • If the patient is an outpatient, the ANC must be reported to the Clozapine REMS Program before clozapine is dispensed.
  • If the patient is an inpatient, the ANC must be reported within 7 days of the most recent blood sample.
  • Patients with benign ethnic neutropenia (BEN) can now be treated with clozapine.

This article originally appeared on MPR.

New York Times Report: A.D.H.D. Seen in 11% of U.S. Children as Diagnoses Rise

A.D.H.D. Seen in 11% of U.S. Children as Diagnoses Rise

Alarm bells are going off: 11 percent of school-age children over all have received a medical diagnosis of attention deficit hyperactivity disorder, according to new data from the federal Centers for Disease Control and Prevention.

About two-thirds of those with a current diagnosis receive prescriptions for stimulants like Ritalin or Adderall, which can drastically improve the lives of those with A.D.H.D. but can also lead to addiction, anxiety and occasionally psychosis.

Dr. William Graf, a pediatric neurologist in New Haven and a professor at the Yale School of Medicine states, “Mild symptoms are being diagnosed so readily, which goes well beyond the disorder and beyond the zone of ambiguity to pure enhancement of children who are otherwise healthy.”

While some doctors and patient advocates have welcomed rising diagnosis rates as evidence that the disorder is being better recognized and accepted, others said the new rates suggest that millions of children may be taking medication merely to calm behavior or to do better in school. Pills that are shared with or sold to classmates — diversion long tolerated in college settings and gaining traction in high-achieving high schools — are particularly dangerous, doctors say, because of their health risks when abused.

The findings were part of a broader C.D.C. study of children’s health issues, taken from February 2011 to June 2012. The agency interviewed more than 76,000 parents nationwide by both cellphone and landline and is currently compiling its reports.

Read More:  ADHD Overdiagnosed


Over 128 Countries Support Ariana-Leilani’s Right to Health

Ariana-Leilani Supporters All Over the World

Ariana-Leilani Supporters All Over the World

Join them…..before it is too late to help her…please!


The CIA’s Experiments on Children

The Hidden Tragedy of the CIA's Experiments on Children
(Image: Lance Page / t r u t h o u t😉

Bobby is seven years old, but this is not the first time he has been subjected to electroshock. It’s his third time. In all, over the next year, Bobby will experience eight electroshock sessions. Placed on the examining table, he is held down by two male attendants while the physician places a solution on his temples. Bobby struggles with the two men holding him down, but his efforts are useless. He cries out and tries to pull away. One of the attendants tries to force a thick wedge of rubber into his mouth. He turns his head sharply away and cries out, “Let me go, please. I don’t want to be here. Please, let me go.” Bobby’s physician looks irritated and she tells him, “Come on now, Bobby, try to act like a big boy and be still and relax.” Bobby turns his head away from the woman and opens his mouth for the wedge that will prevent him from biting through his tongue. He begins to cry silently, his small shoulders shaking and he stiffens his body against what he knows is coming.

Many of the experiments used drugs that have known side effects of neutropenia.

One of the commenters writes:

Thank you. I would add that these people were just a few of the many participating as CIA contractors out of Johns Hopkins, Georgetown University Hospital, and other prestigious institutions – always under the radar, of course, which is pretty convenient when you have a mission to be secret and a black budget. For those commenters who find it difficult to believe even after reading such a thoroughly supported article, just consider this was the tip of the iceberg. As for motive, it was ultimately about power and control. How much can the mind be manipulated for the “good” of mankind? How much can the brain and brain development be manipulated? (As was stated, the origins of these programs were in Nazi Germany and brought here thanks to a program called PROJECT PAPERCLIP.) I spent second half of the sixties, from age six to age 10 in a drug-induced daze or throwing up because of the effects of the drugs. My Naval Intelligence father – who had been led to believe I was in a “gifted child” program and was kept in the dark about what was being done – finally made the connection when he had to rush me to the hospital. He pulled me out of the program immediately, and was burned for his trouble and blacklisted for the rest of his life. (I actually had to be sent across the country to a safehouse; it might sound like a movie but I can assure you it was very very real and horrifying.) Our family has waited decades for more of this information to become public, hoping it was only a matter of time. There are good people working in the CIA with genuinely good intentions, but the CIA as an institution is an agent of absolute evil. It only takes one glance at the horror that is Blackwater (and there is a connection, but I won’t go into it here) to understand this.

Read More:

CIA Experiments on Children

Alone We Are Rare, Together We are Strong — Rare Disease Day USA

March 1, 2013 Is Rare Disease Day

March 1, 2013 Is Rare Disease Day

Alone we are rare. Together we are strong.

Today is Rare Disease Day
Make Your Voice Heard

Today is the day that people living with rare diseases speak with a single voice, all around the world.

There have been weeks or months of preparation in many countries. Now, the day is here and it’s the time for all of us to take a stand on behalf of all patients and families affected by rare diseases.

Rare Disease Day has special significance in the U.S. this year because it’s the 30th anniversary of the Orphan Drug Act and the establishment of NORD.

In addition, federal budget cuts are slated to go into effect tomorrow that could significantly affect medical research at the National Institutes of Health (NIH) and the Rare Disease Program at the Food and Drug Administration (FDA).

Please take a few minutes to read the letter posted by NORD and either submit it as it is to your elected officials or personalize it with your own information.

Last year, more than 16,000 letters were submitted during the 24-hour Handprints on the Hill campaign for Rare Disease Day. All states were represented. This year, we hope to have even more letters submitted … especially with these looming budget cuts.

Thank you for supporting the Handprints on the Hill campaign and for making your voice heard.

– NORD – National Organization for Rare Disorders, Inc.

Ariana-Leilani suffers from the rare disease of Severe Chronic Neutropenia.


Georgetown University Hospital Has History of Involvement with CIA Drug Experimentation

Central Intelligence Agency Seal

A long forgotten 1977 article in the New York times, reveals that the Central Intelligence Agency partnered with institutions, including Georgetown University Hospital, to test drugs on unwitting patients.  The CIA even contributed 375,000 towards construction of a GUH building.    The relationship was exposed through efforts of Senator Ted Kennedy of Massachusetts.

Georgetown University is also the school which the lawyer who is fighting to prevent Ariana-Leilani from getting a second opinion graduated, and also that of his own father.  A position at Georgetown University was used as cover for the father when he was in the CIA, as highlighted in his book, King’s Counsel

Read More: CIA Behavior Control Studies Reported in New York Times


With the USA Failing to Ratify the 20 Year Old UN Convention on the Rights of the Child, Can You Fault Putin?

Vladimir Putin - World Economic Forum Annual M...

Vladimir Putin – World Economic Forum Annual Meeting Davos 2009 (Photo credit: World Economic Forum)

President Vladimir Putin on Friday signed a law banning Americans from adopting Russian children.    Putin accused the United States of “acting brazenly and arrogantly” by allegedly refusing Russian officials access to adopted children who were reported to be harmed by their new US families.

The USA has done the same with Ariana-Leilani, where the German Government has requested an independent medical and psychological examination and life saving medicine for Ariana-Leilani, but the USA has refused to do so.

Putin cited Israel as an example of a country that does not send its children abroad despite domestic concerns about the security situation there.  The Israelis “always fight for their national identity”, said Putin. “They form a single fist and fight for their language and their culture.”

With the United States failing to ratify the UN Convention on the Rights of the Child, and specifically ignoring 9 year old German-American Ariana-Leilani’s right to health, can you blame Putin?

Tell President Obama to show how the USA can protect children’s rights, sign the petition to get the USA to take action to protect 9 year old Ariana-Leilani.

Your signature makes a difference.  Please sign the petition.


Childrens Rights, Not Gun Rights, Needed in USA: The Case of 9 Year Old Ariana-Leilani Falling Through the Cracks in the USA

Watch the video broadcast of PressTV, December 19, 2012, reporting on Ariana-Leilani falling through the cracks, and the US Failure to ratify the UN Convention on the Rights of the Child after 20 years.  Why does the USA give more rights to gun owners than to children?
Ariana-Leilani Discussed On Press TV

Ariana-Leilani Discussed On Press TV

PressTV Reporter Marjon Asi writes:
The right to health, life, identity and protection from abuse. These are some of the major rights outlined in the 1989 United Nations Convention on the Rights of the Child. Almost every country in the UN is bound to it- except the United States and Somalia.

The UN NGO Innocence in Danger organized a press conference addressing this issue, stating the potential harm this may have on children in the United States. 

One example of the effects of US non-membership to the global children’s rights treaty is Ariana Leilani King, a ten year old girl with dual German-American citizenship, who has medical problems that organizers state are not being properly addressed by the U.S. government. 

For many Americans, this is a major cause of embarrassment, including President Obama who vowed to revive efforts to join the treaty when he first came to office in 2009. But three years later, this remains to be seen. 

Many children’s rights advocates are speaking out against the US position, demanding that the government ratify the treaty. 

Earlier this month the US Senate also voted against joining the UN Convention on the Rights of the Disable



Your signature makes a difference.  Please sign the petition.

Related articles

Celebrate the UN Day for Girl Child: Sign Today

Official portrait of Secretary of State Hillar...

Official portrait of Secretary of State Hillary Rodham Clinton. (Photo credit: Wikipedia)

The UN International Day for the Girl Child was celebrated in Washington DC and around the world.  In Washington DC, US Secretary State Hillary Clinton and Desmond Tutu, and others, celebrated.

Ariana-Leilani is one girl child that needs their help.  She needs lifesaving medicine and medical care — right there in Washington DC.  Let them know that you support getting Ariana-Leilani the help she needs.  Sign her petition today.


Ariana-Leilani and her mother Dr. Ariel King

Dangerous Trend: Neutroprenia-Inducing ADHD Medicine Becoming Common As “Medicine” for Underperforming Kids

English: Percent of Youth 4-17 ever diagnosed ...

English: Percent of Youth 4-17 ever diagnosed with Attention-Deficit/Hyperactivity Disorder: National Survey of Children’s Health, 2007 (Photo credit: Wikipedia)

ADHD medicines, like Concerta, have known side effects of Neutropenia.   The medicines are commonly thought to be harmless, when in fact they are “uppers” and have the side effects of neutropenia in some patients, such as Ariana-Leilani.  Yet, they are now being abused by schools and parents to boost the performance of children, including those, like Ariana-Leilani, who do not actually have ADHD.

Read More: Attention Disorder or Not, Pills to Help in School

2005-Powerpoint Presentation on Concerta and Neutropenia

2005-US Department of Health and Human Services Memo on Concerta and Neutropenia